Publications

Link To: Google Scholar – Brodland

Neil M Neumann, Matthew C Perrone, Jim H Veldhuis, Robert J Huebner, Huiwang Zhan, Peter N Devreotes, G Wayne Brodland, Andrew J Ewald, 2018, “Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation”,Developmental Cell, 45, 67-82, e6 doi.org/10.1016/j.devcel.2018.03.011

Christian Balkovec, Jim Veldhuis, John W Baird, G Wayne Brodland, Stuart M McGill, 2018, “Digital tracking algorithm reveals the influence of structural irregularities on joint movements in the human cervical spine”, Clinical Biomechanics, 56, 11-17 doi.org/10.1016/j.clinbiomech.2018.04.015

Jim H Veldhuis, Ahmad Ehsandar, Jean-Léon Maître, Takashi Hiiragi, Simon Cox, G Wayne Brodland, 2017, "Inferring cellular forces from image stacks”, Philosophical Transactions of the Royal Society B, 372, 20160261. doi: 10.1098/rstb.2016.0261.

Christian Balkovec, Jim H Veldhuis, John W Baird, G Wayne Brodland, Stuart M McGill, 2017, “A videofluoroscopy-based tracking algorithm for quantifying the time course of human intervertebral displacements”, Computer Methods in Biomechanics and Biomedical Engineering, 20, 794-802. doi.org/10.1080/10255842.2017.1302435

SF Gabriel Krens, Jim H Veldhuis, Vanessa Barone, Daniel Čapek, Jean-Léon Maître, G Wayne Brodland, Carl-Philipp Heisenberg, 2017, Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation, Development, 144, 1798-1806. doi: 10.1242/dev.144964

Matthew C Perrone, Jim H Veldhuis, G Wayne Brodland, 2016, "Non-straight cell edges are important to invasion and engulfment as demonstrated by cell mechanics model," Biomechanics and Modeling in Mechanobiology, pp. 1-14. doi:10.1007/s10237-015-0697-6 (open access).

Brodland, G.W., 2015, "How computational models can help unlock biological systems," Seminars in Cell & Development Biology. doi:10.1016/j.semcdb.2015.07.001 (open access).

Veldhuis, J.H., Mashburn, D., Hutson, M.S., Brodland, G.W., 2015, "Practical aspects of the cellular force inference toolkit (CellFIT)," Methods in cell biology, Vol. 125, pp. 331-351. doi:10.1016/bs.mcb.2014.10.010.

Brugues, A., Anon, E., Conte, V., Veldhuis, J., Gupta, M., Colombelli, J., Munoz, J., Brodland, G.W., Ladoux, B., Trepat, X., 2014, "Forces driving epithelial wound healing," Nature Physics, Vol. 10, pp. 683-690. doi:10.1038/nphys3040.

Brodland, G.W, Veldhuis, J.H., Kim, S., Perrone, M., Mashburn, D., Hutson, M.S., 2014, "CellFIT: A Cellular Force-Inference Toolkit Using Curvilinear Cell Boundaries," PLoS ONE, Vol. 9, No. 6, e99116. doi: 10.1371/journal.pone.0099116.

Gibson, W.T., Rubinstein, B., Meyer,E., Veldhuis, J.H., Brodland, G.W., Nagpal,R., Gibson, M.C., 2014, "On the origins of the mitotic shift in proliferating cell layers," Theoretical Biology and Medical Modelling, Vol. 11, No. 1, pp. 26-44. doi:10.1186/1742-4682-11-26.

Lynch, H.E., Veldhuis, J.H., Brodland, G.W., Hutson, M.S., 2014, "Modeling cell elongation during germ band retraction: cell autonomy versus applied anisotropic stress," New journal of Physics, Vol. 16, No. 5, 055003. doi:10.1088/1367-2630/16/5/055003.

Brodland, G.W. and Veldhuis, J.H., 2012, "Assessing the Mechanical Energy Costs of Various Tissue Reshaping Mechanisms," Biomechanics and Modeling in Mechanobiology, Vol. 11, No. 8, pp. 1137-1147. doi: 10.1007/s10237-012-0411-x.

Brodland, G.W. and Veldhuis, J.H., 2012, "The Mechanics of Metastasis: Insights from a Computational Model," PLoS ONE, Vol 7, No. 9, e44281, pp. 1-11. doi:10.1371/journal.pone.0044281.

Horst, C., Brodland B.T.L., Jones, L.W. and Brodland G.W., 2012, "Measuring the Modulus of Silicone Hydrogel Contact Lenses," Optometry and Vision Science, Vol. 89, No. 10, pp. 1468-1476. doi:10.1097/OPX.0b013e3182691454.

Conte, V., Ulrich, F., Bam, B., Junoz, J., Veldhuis, V., Brodland, W., and Miodownik, M., 2012, "A biomechanical analysis of ventral furrow formation in the Drosophila melanogaster embryo," PLoS ONE, Vol. 7, No. 4, e34473, pp. 1-17. doi:10.1371/journal.pone.0034473.

Brodland, G.W., 2011, "A Framework for Connecting Gene Expression to Morphogenetic Movements in Embryos," IEEE Transactions on Biomedical Engineering, Vol. 58 (10), pp3033-3036. doi:10.1109/TBME.2011.2159604.

Azevedo,D., Antunes, M., Prag, S., Ma, X., Hacker, U., Brodland, G.W., Hutson, M.S., Solon, J., Jacinto, A., 2011, "DRhoGEF2 Regulates Cellular Tension and Cell Pulsations in the Amnioserosa during Drosophila Dorsal Closure," PLoS ONE 6(9): e23964. doi:10.1371/journal.pone.0023964.

Gregory, D.E., Veldhuis, J.H., Horst, C., Brodland, G.W., Callaghan, J.P., 2011, "Novel lap test determines the mechanics of delamination between annular lamellae of the intervertebral disc," Journal of Biomechanics, Vol. 44, pp. 97-102. doi: 10.1016/j.jbiomech.2010.08.031.

Gibson, W.T., Veldhuis, J.H., Rubinstein, B., Cartwright, H.N., Perrimon, N., Brodland, G.W., Nagpal, R., Gibson, M.C., 2011, "Control of the mitotic cleavage plane by local epithelial topology," Cell, Vol. 144, pp. 427-438. doi: 10.1016/j.cell.2010.12.035.

Leung, K-S, Veldhuis, J.H., Krens, S.F.G., Heisenberg, C.P., Brodland, G.W., 2011, "Identifying Same-Cell Contours in Image Stacks: A Key Step in Making 3D Reconstructions," Annals of Biomedical Engineering, Vol. 39, pp. 698-705. doi: 10.1007/s10439-010-0198-9.

Brodland, G.W., Conte, V. Cranston, P.G., Veldhuis, J., Narasimhan, S., Hutson, M.S., Jacinto, A., Ulrich, F., Baum, B., and Miodownik, M., 2010, "Video Force Microscopy Reveals the Mechanics of Ventral Furrow Invagination in Drosophila," Proceedings of the National Academy of Sciences (PNAS), Vol 107, No. 51, pp. 22111-22116. doi: 10.1073/pnas.1006591107 (open access).

Brodland, G.W., Chen, X., Lee, P. and Marsden, M., 2010, "From genes to neural tube defects (NTDs): Insights from multiscale computational modeling," HFSP Journal, Vol. 4, pp. 142-152. doi: 10.2976/1.3338713.

Cranston, P.G., Veldhuis, J.H., Narasimhan, S. and Brodland, G.W., 2010, "Cinemechanometry (CMM): A Method to Determine the Forces Driving Morphogenetic Movements from Time-lapse Images," Annals of Biomedical Engineering, Vol. 38, pp. 2937-2947. doi: 10.1007/s10439-010-9998-1.

Eilaghi, A., Flanagan, J.G., Tertinegg, I., Simmons, C.A., Brodland, G.W., Ethier, C.R., 2010, "Biaxial Mechanical Testing of Human Sclera," Journal of Biomechanics, Vol. 43, pp. 1696-1701. doi: 10.1016/j.jbiomech.2010.02.031.

Hutson, M.S., Veldhuis, J., Ma, X., Lynch, H.E., Cranston, P.G., and Brodland, G.W., 2009, "Combining laser microsurgery and finite element modeling to assess cell-level epithelial mechanics," Biophysical Journal, Vol. 97, pp. 3075-3085. doi: 10.1016/j.bpj.2009.09.034.

Siva, P., Brodland, G.W. and Clausi, D., 2009, "Detecting Mitoses in Time-lapse Images of Embryonic Epithelia Using Intensity Analysis," Annals of Biomedical Engineering, Vol. 37, pp. 2646-2655. doi: 10.1007/s10439-009-9790-2.

Brodland, G.W., Yang, J and Sweny, J, 2009, "Cellular interfacial and surface tensions determined from aggregate compression tests using a finite element model," HFSP Journal, Vol. 3, pp. 273-281. doi: 10.2976/1.3175812.

Brodland, G.W. and Yang, J, 2009, "Estimating interfacial tension from the shape histories of cells in compressed aggregates: a computational study," Annals of Biomedical Engineering, Vol. 37, pp. 1019-1027. doi: 10.1007/s10439-009-9649-6.

Siva, P., Brodland, G.W. and Clausi, D., 2009, "Detection of Mitoses in Embryonic Epithelia Using Motion Field Analysis," Computer Methods in Biomechanics and Biomedical Engineering, Vol. 12, pp. 151-163. doi: 10.1080/10255840802609412.

Eilaghi, A., Flanagan, J.G., Brodland, G.W. and Ethier, C.R., 2009, "Strain Uniformity in Biaxial Specimens is Highly Sensitive to Attachment Details," ASME Journal of Biomechanical Engineering, Vol. 131, 091003. doi: 10.1115/1.3148467.

Chen, X., and Brodland, G.W., 2008, "Mechanical Determinants of Epithelium Thickness in Early-stage Embryos," Journal of the Mechanical Behavior of Biomedical Materials, Vol. 2, pp. 494-501. doi: 10.1016/j.jmbbm.2008.12.004.

Hutson, S.L., Brodland, G.W., Yang, J. and Viens, D., 2008, "Cell Sorting in Three Dimensions: Topology, Fluctuations, and Fluidlike Instabilities," Physical Review Letters, Vol. 101, 148105. doi: 10.1103/PhysRevLett.101.148105.

Chen, X. and Brodland G.W., 2008, "Multi-scale Finite Element Modeling Allows the Mechanics of Amphibian Neurulation to be Elucidated," Physical Biology, Vol. 5 (1), pp. 1-15. doi: 10.1088/1478-3975/5/1/015003.

Benko, R. and Brodland, G.W., 2007, "Measurement of in vivo Stress resultants in Neurulation-stage Amphibian Embryos," Annals of Biomedical Engineering, Vol. 35 (4) pp 672-681.10.1007/s10439-006-9250-1.

Viens, D., and Brodland, G.W., 2007, "A Three-dimensional Finite Element Model for the Mechanics of Cell-Cell Interactions," ASME Journal of Biomechanical Engineering, Vol. 129, pp. 651-657. doi: 10.1115/1.2768375.

Brodland, G.W., Viens, D. and Veldhuis, J.H., 2007, "A New Cell-based FE Model for the Mechanics of Embryonic Epithelia," Computer Methods in Biomechanics and Biomedical Engineering, Vol 10 (2), pp. 121-128. doi: 10.1080/10255840601124704.

Iles, P.J.W., Brodland, G.W., Clauis, D.A., and Puddister, S.M., 2007, "Estimation of Cellular Fabric in Embryonic Epithelia," Computer Methods in Biomechanics and Biomedical Engineering, Vol. 10 (1),  pp. 75-84. doi: 10.1080/10255840601066848.

van Sligtenhorst, C., Cronin, D.S., and Brodland, G.W., 2006, "High Strain Rate Compressive Properties of Bovine Muscle Tissue Found Using a Split Hopkinson Bar Apparatus", Journal of Biomechanics, 39 (10), pp. 1852-1858. doi: 10.1016/j.jbiomech.2005.05.015.

Brodland, G.W. and Veldhuis, J.H., 2006, "Lamellipodium-driven Tissue Reshaping: A Parametric Study", Computer Methods in Biomechanics and Biomedical Engineering, Vol. 9 (1), pp. 17-23. doi: 10.1080/10255840600554703.

Brodland, G.W., 2006, "Do lamellipodia have the mechanical capacity to drive convergent extension?" International Journal of Developmental Biology, Vol. 50, pp. 151-155. doi: 10.1387/ijdb.052040gb.

Brodland, G.W., Chen, D.I.-L., and Veldhuis, J.H., 2006, "A Cell-based Constitutive Model for Embryonic Epithelia and Other Planar Aggregates of Biological Cells," International Journal of Plasticity, Vol. 22, pp. 965-995. 10.1016/j.ijplas.2005.05.002.

Wiebe, C.J. and Brodland, G.W., 2005, "Tensile Properties of Embryonic Epithelia Measured Using a Novel Instrument," Journal of Biomechanics, Vol. 38, pp. 2087-2094. doi: 10.1016/j.jbiomech.2004.09.005.

Bootsma, G.J. and Brodland, G.W., 2005, "Automated 3D Reconstruction of the Surface of Live Early-stage Amphibian Embryos", IEEE Transactions on Biomedical Engineering, Vol. 52, pp. 1407-1414. doi: 10.1109/TBME.2005.851500.

Veldhuis, J.H., Brodland, G.W., Wiebe, C.J., and Bootsma, G.J., 2005, "Multiview Robotic Microscope Reveals the In-plane Kinematics of Amphibian Neurulation," Annals of Biomedical Engineering, Vol. 33, pp. 821-828. 10.1007/s10439-005-3309-2.

Brodland, G.W., and Wiebe, C.J., 2004, "Mechanical Effects of Cell Anisotropy in Epithelia," Computer Methods in Biomechanics and Biomedical Engineering, Vol. 7, pp. 91-99. doi: 10.1080/1025584042000209369.

Brodland, G.W., 2004, "Computer Modeling of Cell Sorting, Tissue Engulfment and Related Phenomena: A Review," ASME Applied Mechanics Reviews, Vol. 57, pp. 1-30. doi: 10.1115/1.1583758.

Fox, S.R., and Brodland, G.W., 2003, "Design Expressions Based on a FE Model of a Stiffened CFS C-Section", ASCE Journal of Structural Engineering, Vol. 130, pp. 708-714. doi: 10.1061/(ASCE)0733-9445(2004)130:5(708).

Brodland, G.W., 2003, "New Information from Cell Aggregate Compression Tests and Implications for Theories of Cell Sorting," Biorheology, Vol. 40, pp. 273-277. URL.

Brodland, G.W., and Veldhuis, J.H., 2003, "A Computer Model for Cell Reshaping in Epithelia due to In-plane Deformation and Annealing," Computer Methods in Biomechanics and Biomedical Engineering, Vol. 6, pp. 89-98. doi: 10.1080/1025584031000078934.

Brodland, G.W., and Veldhuis, J.H., 2002, "Computer Simulations of Mitosis and Interdependencies Between Mitosis, Cell Shape and Epithelium Reshaping," Journal of Biomechanics, Vol. 35, pp. 673-681. URL.

Brodland, G.W., 2002, "The Differential Interfacial Tension hypothesis (DITH): A Comprehensive Theory for Self-Rearrangement of Embryonic Cells and Tissues," ASME Journal of Biomechanical Engineering, Vol. 124, pp. 188-197. pdf

Chen, H.H., and Brodland, G.W., 2000, "Cell-level Finite Element Studies of Viscous Cells in Planar Aggregates", ASME Journal of Biomechanical Engineering, Vol. 122, pp. 394-401. pdf

Brodland, G.W. and Chen, H.H., 2000a, "The Mechanics of Heterotypic Cell Aggregates: Insights from Computer Simulations", ASME Journal of Biomechanical Eng., Vol. 122, pp. 402-407. pdf

Brodland, G.W. and Dolovich, A.T., 2000, "Curved-Ray Technique to Measure the Stress Profile in Tempered Glass", Optical Engineering, Vol. 39, pp. 2501-2505. pdf

Brodland, G.W. and Chen, H.H., 2000b, "The Mechanics of Cell Sorting and Envelopment", Journal of Biomechanics, Vol. 33, pp. 845-851. pdf

Veldhuis, J.H., and G.W. Brodland, 1999, "A Deformable Block-matching Algorithm for Tracking Epithelial Cells", Image and Vision Computing, Vol. 17, 905-911. pdf

G.W. Brodland, and Veldhuis, J.H.,1998, "3D Reconstruction of Live Embryos Using Robotic Macroscope Images", IEEE Transactions on Biomedical Engineering, Vol. 45, No. 9, pp. 1173-1181. pdf

Brodland, G.W., and H.H. Chen, 1997, "Computer Simulations of the Mechanics of Embryo Morphogenesis," Advanced Mechanics, (Invited, and reviewed; in Chinese) Vol. 27, No. 4, pp. 464-478.

Rehkopf, J.D., G.W. Brodland, and G.M. McNeice, 1996, "Experimentally Separating Fluid and Matrix Contributions to Polymeric Foam Behaviour," Experimental Mechanics, Vol. 36, No. 1, pp. 1-6.

Rehkopf, J.D., G.M. McNeice, and G.W. Brodland, 1996, "Fluid and Matrix Components of Polyurethane Foam Behaviour Under Cyclic Compression," ASME Journal of Engineering Materials and Technology, Vol. 118, pp. 58-62.

Brodland, G.W., Scott, M.J., MacLean, A.F., Globus, M, Vethamany-Globus, S., Gordon, R., VeldHuis, J.H., and DelMaestro, R., 1996, "Morphogenetic Movements During Axolotl Neural Tube Formations Tracked by Digital Imaging," Roux's Archives for Developmental Biology, Vol. 205, pp. 311-318.

Brodland, G.W., and D.A. Clausi, 1995, "Cytoskeletal Mechanics of Neuralation: Insights Obtained from Computer Simulations," Biochemistry and Cell Biology, Vol. 73, pp. 545-553.

Dolovich, A.T., and G.W. Brodland, 1995, "Convergence Acceleration for Iterative Finite Element Methods,"ASCE Journal of Engineering Mechanics, Vol. 121, pp. 1-6.

Brodland, G.W., and D.A. Clausi, 1994, "Embryonic Tissue Morphogenesis Modeled by FEM," ASME Journal of Biomechanical Engineering, Vol. 116, pp. 146-155.

Brodland, G.W., Gordon, R., Scott, M.J., Bjorklund, N.K., Luchka, K.B., Martin, C.C., Matuga, C., M. Globus, S. Vethamany-Globus, and Shu, D., 1994, "Furrowing Surface Contraction Wave Coincident with Primary Neural Induction in Amphibian Embryos," Journal of Morphology, Vol. 219, pp. 131-142.

Brodland, G.W., M.J. Dell and E.F.P. Burnett, 1993, "Large-strain Analysis of Reinforced Membranes," ASCE Journal of Engineering Mechanics, Vol. 119, No. 12, pp. 2461-2477.

Clausi, D.A., and G.W. Brodland, 1993, "Mechanical Evaluation of Theories of Neuralation Using Computer Simulation," Development, Vol. 118, pp. 1013-1023. pdf

Brodland, G.W., and E.F.P. Burnett, 1993, "Mechanics and Failure of Multi-Layer, Reinforced Membranes," ASCE Journal of Materials in Civil Engineering, Vol. 5, No. 3, pp. 293-307.

Brodland, G.W., A.T. Dolovich, and J.E. Davies, 1992, "Pre-tension Critically Affects the Incremental Strain Field on Pressure-Loaded Cell Substrates," ASME Journal of Biomechanical Engineering, Vol. 114, No. 3, pp. 418-420.

Brodland, G.W. and G. Welstead, 1991, "Students Consolidate Learning by Designing Course Modules," International Journal of Applied Engineering Education, Vol. 7, No. 4, 252-257.

Gordon, R., and G.W. Brodland, 1990, "On Square Holes in Pennate Diatoms," Diatom Research, Vol. 5, No. 2, pp. 409-413.

Brodland, G.W., and R. Gordon, 1990, "Intermediate Filaments May Prevent Buckling of Compressively Loaded Microtubules," Journal of Biomechanical Engineering, Vol. 112, August, pp. 319-321.

Brodland, G.W., and H. Cohen, 1989, "Deflection and Snapping of Ring-Loaded Spherical Caps," ASME Journal of Applied Mechanics, Vol. 56, March, pp. 127-132.

Thompson, J. C. and G.W. Brodland, 1988,"Analysis of Strain Averaged Data from Finite Length Gauges and Predictions of Peak Strains for Planar Notch and Fillet Problems," Strain, Vol. 24, No. 4, November, pp. 147-152.

Dolovich, A.T., G.W. Brodland and A.B. Thornton-Trump, 1988, "An Approximate Solution of the Axisymmetric von Karman Equations for a Point-Loaded Circular Plate," ASME Journal of Applied Mechanics, Vol. 55, March, pp. 241-243.

Discussion and Author's Closure, Vol. 55, Sept. 1988, pp. 746-747.

Brodland, G.W., 1988, "Highly Nonlinear Deformation of Uniformly Loaded Circular Plates," International Journal of Solids and Structures, Vol. 24, No. 4, pp. 351-362.

Gordon, R., and G.W. Brodland, 1987, "The Cytoskeletal Mechanics of Brain Morphogenesis: Cell State Splitters Cause Primary Neural Induction," Cell Biophysics, Vol. 11, pp. 177-238.

Brodland, G.W., and A.B. Thornton-Trump, 1987, "Gait Force Reconstruction and a Heel Strike Algorithm," Journal of Biomechanics, Vol. 20, No. 8, pp. 767-772.

Brodland, G.W., and H. Cohen, 1987, "Large-Strain Axisymmetric Deformation of Cylindrical Shells," ASME Journal of Applied Mechanics, Vol. 54, June, pp. 287-291.

Brodland, G.W., and H. Cohen, 1987, "Deflection and Snapping of Spherical Caps," International Journal of Solids and Structures, Vol. 23, No. 10, pp. 1341-1356.

Brodland, G.W., 1986, "Nonlinear Deformation of Uniformly Loaded Circular Plates," Solid Mechanics Archives, Vol. 11, No. 4, pp. 219-256.